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  • Writer's pictureAllison Flanagan

Lymphedema vs Lipodema

Updated: Jan 4, 2021

Differences between Lipedema and Lymphedema

Lipedema is a chronically progressive, symmetrical accumulation of fat in the subcutaneous tissue occurring almost exclusively in women. Primarily the lower extremities are affected, but lipedema may occur in combination with the upper extremities as well. Lipedema is characterized by symmetric enlargement of the limbs, combined with tenderness and easy bruising.

Lipedema is not caused by a disorder of the lymphatic system; however, it is commonly misdiagnosed as bilateral primary lymphedema.

Several marked differences between lipedema and primary lymphedema can be distinguished; these differences are highlighted in the table below.

While lipedema always affects both legs symmetrically (bilateral appearance), primary lymphedema usually affects one leg only. If both legs are involved in primary lymphedema the swelling appears asymmetric (see image on bottom of this article). The feet are not involved in lipedema; the symmetrical distribution of fat is located between the hips and the ankles.

In contrast, the feet in lymphedema are involved in the swelling, and a diagnostic indicator known as the Stemmer sign is positive.

The Stemmer sign is a diagnostic test that involves pinching the skin on the upper surface of the toe (usually second toe) or fingers. If a fold of skin can be pinched and lifted up at the base of the second toe or middle finger, the Stemmer sign is negative. The Stemmer sign is positive and indicative of lymphedema when a skin fold cannot be lifted, but can only be grasped as a lump of tissue. This sign will become positive if lipedema develops into lipo-lymphedema.

Tissue in lipedema has a soft rubber-like feel in early stages and may include small fatty lumps (nodules) within the tissues in later stages. Pressure with the thumb does not leave an indentation (no pitting) in lipedema. Lymphedema is pitting and the tissue feels firmer than in lipedema, especially with fibrotic tissue typically being present starting in stage 2. The cause for the onset of lymphedema are malformations of the lymphatic system, while the underlying cause for the development of lipedema remains unknown; it is thought to be associated with hormonal disorders.

Differences at a Glance:

Lipedema Lymphedema

Symmetric (buttocks involved) Not symmetric

Foot not involved Foot involved

Not pitting Pitting edema

Stemmer sign negative Stemmer sign positive

Tissue feels rubbery Tissue feels firmer (starting stage 2 lymphedema)

Painful to touch Generally not painful to touch

Easy bruising Generally not bruising

Hormonal disturbances frequent Generally no hormonal disturbance

Additional Reading:

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